THE DESIGN AND SYNTHESIS OF NOVEL ADENOSINE AGONISTS

Authors
SCAMMELLS PJ BAKER SP BELLARDINELLI L OLSSON RA RUSSELL RA KNEVITT SA
Citation
Pj. Scammells et al., THE DESIGN AND SYNTHESIS OF NOVEL ADENOSINE AGONISTS, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 811-814
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
811 - 814
Database
ISI
SICI code
0960-894X(1996)6:7<811:TDASON>2.0.ZU;2-L
Abstract
The 2R and 2S-endo isomers of N-6-(5,6-epoxynorborn-2-yl)adenosine hav e been synthesised and shown to be potent agonists for the At adenosin e receptor. The 2S-endo isomer was equipotent to N-6-cyclopentyladenos ine and 10- to 12-fold more potent than the 2R-endo isomer. Copyright (C) 1996 Elsevier Science Ltd