SYNTHESIS OF 7-ALPHA-METHOXY-2-(1,3-DITHIOLAN-2-YLIDENE)CEPHEM SULFONES - A NEW SERIES OF HUMAN-LEUKOCYTE ELASTASE INHIBITORS

Authors
MAITI SN CZAJKOWSKI DP REDDY NAV SPEVAK P KALETA J MICETICH RG
Citation
Sn. Maiti et al., SYNTHESIS OF 7-ALPHA-METHOXY-2-(1,3-DITHIOLAN-2-YLIDENE)CEPHEM SULFONES - A NEW SERIES OF HUMAN-LEUKOCYTE ELASTASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 823-826
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
823 - 826
Database
ISI
SICI code
0960-894X(1996)6:7<823:SO7S>2.0.ZU;2-6
Abstract
Treatment of 3-methyl-3-cephem sulphone with sodium hydride followed b y carbon disulphide and alkyl halide provides an entry to 2-(1,3-dioth iolan-2-ylidene) -cephem derivatives, which are new potent inhibitors of HSE. Copyright (C) 1996 Elsevier Science Ltd