OXIRANES WITH QUINOLINE SUBSTITUTION - STEREOSELECTIVE SYNTHESIS AND ANTIVIRAL ACTIVITY

Authors
KIDWAI M KUMAR K GOEL Y SRIVASTAVA KC
Citation
M. Kidwai et al., OXIRANES WITH QUINOLINE SUBSTITUTION - STEREOSELECTIVE SYNTHESIS AND ANTIVIRAL ACTIVITY, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 871-874
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
871 - 874
Database
ISI
SICI code
0960-894X(1996)6:7<871:OWQS-S>2.0.ZU;2-J
Abstract
A series of new quinoline substituted oxiranes were synthesised by the reaction of 2-N-(chloroacetyl)-1-(4'-methyl-2'-quinolinyl) hydrazide and aromatic aldehydes. These compounds were tested against encephalom yocarditis virus (EMCV) and only two compounds exhibited protection ag ainst the virus. Copyright (C) 1996 Elsevier Science Ltd