NOVEL 4,4-BIS(TRIFLUOROMETHYL) IMIDAZOLINES AS STEREOSPECIFIC AND ORALLY-ACTIVE ACYL COA - CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS AND ANTIHYPERCHOLESTEROLEMIC AGENTS

Authors
BOSWELL GA LI HY DELUCCA I BILLHEIMER JT DRUMMOND S GILLIES PJ ROBINSON C
Citation
Ga. Boswell et al., NOVEL 4,4-BIS(TRIFLUOROMETHYL) IMIDAZOLINES AS STEREOSPECIFIC AND ORALLY-ACTIVE ACYL COA - CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS AND ANTIHYPERCHOLESTEROLEMIC AGENTS, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 885-888
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
885 - 888
Database
ISI
SICI code
0960-894X(1996)6:7<885:N4IASA>2.0.ZU;2-#
Abstract
A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Com pound 6 and its R-enantiomer 6a exhibited very potent oral activities in lowering the serum cholesterol in the animals. Copyright (C) 1996 E lsevier Science Ltd