BENZOPYRAN SELECTIVE ESTROGEN-RECEPTOR MODULATORS (SERMS) - PHARMACOLOGICAL EFFECTS AND STRUCTURAL CORRELATION WITH RALOXIFENE

Authors
GRESE TA SLUKA JP BRYANT HU COLE HW KIM JR MAGEE DE ROWLEY ER SATO M
Citation
Ta. Grese et al., BENZOPYRAN SELECTIVE ESTROGEN-RECEPTOR MODULATORS (SERMS) - PHARMACOLOGICAL EFFECTS AND STRUCTURAL CORRELATION WITH RALOXIFENE, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 903-908
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
903 - 908
Database
ISI
SICI code
0960-894X(1996)6:7<903:BSEM(->2.0.ZU;2-V
Abstract
Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist acti vity on bone and serum lipid parameters. A structural model that accou nts for the pharmacological similarity of these benzopyrans and the be nzothiophene SERM, raloxifene, is proposed. Copyright (C) 1996 Elsevie r Science Ltd