GLIAL-CELL TRANSPLANTATION AND REMYELINATION OF THE CENTRAL-NERVOUS-SYSTEM

Glial cell transplantation has proved to be a powerful tool in the stu dy of glial cell biology, The extent of myelination achieved by transp lanting myelin-producing cells into the CNS of myelin mutants, or into focal demyelinating lesions has raised hope that such a strategy may have therapeutic applications, Oligodendrocytes or Schwann cells could be used for repair, It is likely that the immature stages of the olig odendrocyte lineage have the best phenotypic characteristics for remye lination when transplanted, either as primary cells or as immortalized cells or cell lines, Prior culturing and growth factor treatment prov ides opportunities to expand cell populations before transplantation a s dissociated cell preparations, Cell lines are attractive candidates for transplantation, but the risk of transformation must be monitored, The application of this technique to human myelin disorders may requi re proof that migration, division and stable remyelination of axons by the transplanted cells can occur in the presence of gliosis and infla mmation.