Mn. Cook et al., ONTOGENY OF HEME OXYGENASE ACTIVITY IN THE HIPPOCAMPUS, FRONTAL CEREBRAL-CORTEX, AND CEREBELLUM OF THE GUINEA-PIG, Developmental brain research, 92(1), 1996, pp. 18-23
Heme oxygenase (HO) catalyzes the oxidation of heme to produce carbon
monoxide (GO), biliverdin and iron. CO is considered to function as a
novel neuronal messenger in the brain analogous to nitric oxide. The o
ntogeny of microsomal HO activity in the hippocampus, frontal cerebral
cortex, and cerebellum of the immature fetal, mature fetal and adult
guinea pig was determined using an optimized assay which quantitated h
eme-derived CO formation by a gas chromatographic method. There was a
distinct developmental profile of HO activity that was similar for all
three brain regions. In particular, HO activity was maximal in the ma
ture fetus compared with the immature fetus and the adult. These data
demonstrate that HO activity is developmentally regulated and that the
re is similar ontogeny of HO activity in the hippocampus, frontal cere
bral cortex, and cerebellum of the guinea pig.