SYNTHESIS AND CHARACTERIZATION OF METAL-COMPLEXES OF THE NUCLEOSIDE 4-GLUCOPYRANOSYLAMINO-2-METHYLTHIO-5-NITROSO-6-OXO PYRIMIDINE

The acidity of the nucleoside, nosylamino-2-methylthio-5-nitroso-6-oxo -pyrimidine dine (H(2)GP) has been studied by potentiometric methods. Complexes of H(2)GP with Ni-II, Cu-II, Zn-II, Cd-II, Hg-II and Ag-I we re prepared and characterized by conductivity measurements, i.r., elec tronic, H-1 and C-13-n.m.r. spectroscopies, and magnetic and thermal m easurements. The nucleoside shows a number of different coordination m odes in the various complexes isolated, acting as a chelating agent, e ither through C(6)=O and the NO group or through C(6)=O and the N(1) a tom, or alternatively as a monodentate ligand through the C(6)=O group .