The purpose of this paper is to link the propensity for innovative act
ivity to spatially cluster to the stage of the industry life cycle. Th
e theory of knowledge spillovers, based on the knowledge production fu
nction for innovative activity, suggests that geographic proximity mat
ters the most where tacit knowledge plays an important role in the gen
eration of innovative activity. According to the emerging literature o
f the industry life cycle, tacit knowledge plays the most important ro
le during the early stages of the industry life cycle. Based on a data
base that identifies innovative activity for individual states and sp
ecific industries for the United States, the empirical evidence sugges
ts that the propensity for innovative activity is shaped by the stage
of the industry life cycle. While the generation of new economic knowl
edge tends to result in a greater propensity for innovative activity t
o cluster during the early stages of the industry life cycle, innovati
ve activity tends to be more highly dispersed during the mature and de
clining stages of the life cycle, particularly after controlling for t
he extent to which the location of production is geographically concen
trated. This may suggest that the positive agglomeration effects durin
g the early stages of the industry life cycle become replaced by conge
stion effects during the latter stages of the industry life cycle.