ANTIOXIDATIVE EFFECT OF SESAMOL AND RELATED-COMPOUNDS ON LIPID-PEROXIDATION

The effect of sesamol and 20 related compounds on the lipid peroxidati on of liposomes induced by Fe2+, on the lipid peroxidation of rat live r microsomes induced by CCl4 or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe2+ were demonstrated. Consequentl y, sesamol and related compounds, such as 3-methoxy-4-hydroxyquinone, isosafrol, isoeugenol, eugenol, 3,4-methylenedioxyaniline, catechol, h ydroxy-hydroquinone, 3,4-dimethoxyaniline and caffeic acid, exhibited powerful inhibitory effects on the lipid peroxidation system investiga ted. In particular, isoeugenol was the most powerful inhibitor among a ll the sesamol-related compounds tested on the lipid peroxidation syst em. In addition, 1,2-methylenedioxybenzene, ferulic acid, and 3,4-meth ylenedioxynitrobenzene were also effective on the lipid peroxidation s ystem of liposomes induced by Fe2+. The correlation between the struct ures of sesamol-related compounds and their inhibitory effect is discu ssed.