THE CULTURE FLUID OF ISARIA JAPONICA-YASUDA AUGMENTS ANTI-SHEEP RED-BLOOD-CELL ANTIBODY-RESPONSE IN MICE

Authors
TAKANO F KIKUCHI Y FUSHIYA S HOJO H NOZOE S YAHAGI N YAHAGI R KONDO Y
Citation
F. Takano et al., THE CULTURE FLUID OF ISARIA JAPONICA-YASUDA AUGMENTS ANTI-SHEEP RED-BLOOD-CELL ANTIBODY-RESPONSE IN MICE, Biological & pharmaceutical bulletin, 19(4), 1996, pp. 641-643
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
19
Issue
4
Year of publication
1996
Pages
641 - 643
Database
ISI
SICI code
0918-6158(1996)19:4<641:TCFOIJ>2.0.ZU;2-O
Abstract
Isaria japonica YASUDA was cultured in a liquid medium, and its cultur e fluid (IJCE) was tested for stimulatory activity to humoral antibody production. IJCE significantly enhanced the production of anti-sheep red blood cell (SRBC) plaque forming cells (PFC) by oral ingestions at 10 and 30 mg/kg/d for 4 consecutive days, either before or after SRBC challenge, It also recovered the reduction of anti-SRBC PFC response and number of spleen cells caused by treatment with 5-fluorouracil. It is suggested that IJCE is a promising source for an immunomodulating tool or medicine.