THEORETICAL AND EXPERIMENTAL EVALUATION OF PHASE-DISPERSION EFFECTS CAUSED BY BRAIN MOTION IN-DIFFUSION AND PERFUSION MR-IMAGING

We investigated intravoxel phase dispersion caused by pulsatile brain motion in diffusion spin-echo pulse sequences. Mathematical models wer e used to describe the spatial and temporal velocity distributions of human brain motion. The spatial distribution of brain-tissue velocity introduces a phase spread over one voxel, leading to signal loss. This signal loss was estimated theoretically, and effects on observed diff usion coefficient and perfused capillary fraction were assessed. When parameters from a diffusion pulse sequence without motion compensation were used, and ECG triggering with inappropriate delay times was assu med, the maximal signal loss caused by brain-motion-induced phase disp ersion was predicted to be 21%. This corresponds to a 95% overestimati on of the diffusion coefficient, and the perfusion-fraction error was small, Corresponding calculations for motion-compensated pulse sequenc es predicted a 1% to 1.5% signal loss due to undesired phase dispersio n, whereas experimental results indicated a signal loss related to bra in motion of 4%.