ENANTIOSELECTIVE REACTION OF (+ -)-1-HYDROXY-5-METHYL-3-VINYLCYCLOHEX-2-ENE AND ITS ACYL DERIVATIVES USING LIPID-LIPASE AGGREGATES IN ORGANIC-SOLVENT/

Authors
SHIMIZU N AKITA H KAWAMATA T
Citation
N. Shimizu et al., ENANTIOSELECTIVE REACTION OF (+ -)-1-HYDROXY-5-METHYL-3-VINYLCYCLOHEX-2-ENE AND ITS ACYL DERIVATIVES USING LIPID-LIPASE AGGREGATES IN ORGANIC-SOLVENT/, Chemical and Pharmaceutical Bulletin, 44(4), 1996, pp. 665-669
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
4
Year of publication
1996
Pages
665 - 669
Database
ISI
SICI code
0009-2363(1996)44:4<665:ERO(->2.0.ZU;2-#
Abstract
The enzymatic esterification or hydrolysis of 1-hydroxy-((+/-)-1), 1-a cetoxy-((+/-)-1) and 1-butyryloxy-5-methyl-3-vinylcyclohex-2-ene ((+/- )-3) was carried out using lipid-lipase aggregates, The esterification of (+/-)-1 provided (1S,5S)-1 with > 99% ee using lipid-lipase ''Aman o P'' with vinyl butyrate as the acylating reagent.