SYNTHESIS OF THE INTERFERON-ALPHA INDUCER IMIQUIMOD BY THERMAL ELECTROCYCLIC REACTIONS OF 1-AZAHEXATRIENE AND 2-AZAHEXATRIENE SYSTEMS

Authors
YOSHIOKA H MATSUYA Y CHOSHI T SUGINO E HIBINO S
Citation
H. Yoshioka et al., SYNTHESIS OF THE INTERFERON-ALPHA INDUCER IMIQUIMOD BY THERMAL ELECTROCYCLIC REACTIONS OF 1-AZAHEXATRIENE AND 2-AZAHEXATRIENE SYSTEMS, Chemical and Pharmaceutical Bulletin, 44(4), 1996, pp. 709-714
Citations number
41
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
4
Year of publication
1996
Pages
709 - 714
Database
ISI
SICI code
0009-2363(1996)44:4<709:SOTIII>2.0.ZU;2-W
Abstract
The interferon-1 inducer imiqnimod (1), possessing an imidazo[4,5-c]qu inoline ring, has been newly synthesized by two routes based on therma l electrocyclic reactions of 1- and 2-azahexatriene systems involving the imidazole 4,5-bond.