FORMATION OF A -(2,6-DI-O-METHYL)-BETA-CYCLODEXTRIN-P-NITROPHENOL INCLUSION COMPOUND BY SEALED-HEATING

The complexes of heptakis-(2,6-di-O-methyl)-beta-cyclodextrin (DM beta CD) and p-nitrophenol (p-NP), which were prepared by sealed-heating a nd a slow evaporation method, were comparatively evaluated, From the r esults of differential scanning calorimetry, powder X-ray diffraction, and infrared spectroscopy, the sealed-heated sample was considered as a nov complex which was different from the slow evaporation complex, Also, the data from a sublimation experiment indicated that the inhibi tion of sublimation of p-NP was observed only in the sealed-heated sam ple, These results suggested that p-NP molecules were included within the cavity of DM beta CD molecules, whereas in case of the slow evapor ation complex, p-NP molecules were located in the intermolecular space among the DM beta CD molecules.