Three novel antioxidative serotonin derivatives were isolated from saf
flower oil cake (Carthamus tinctorius L.). Their structures were estab
lished as 4,4 ''-bis(N-p-coumaroyl)serotonin (1), 4-[N-(p-coumaroyl)se
rotonin-4 ''-yl]-N-feruloylserotonin (2), and 4,4 ''-bis(N-feruloyl)se
rotonin (3). Antioxidative activities of the compounds were measured b
y ferric thiocyanate method and DPPH method, and the compounds showed
strong antioxidative activity.