DIRECT FORMATION OF SECONDARY AND TERTIARY ALKYLZINC BROMIDES AND SUBSEQUENT CU(I)-MEDIATED COUPLINGS

Authors
RIEKE RD HANSON MV BROWN JD
Citation
Rd. Rieke et al., DIRECT FORMATION OF SECONDARY AND TERTIARY ALKYLZINC BROMIDES AND SUBSEQUENT CU(I)-MEDIATED COUPLINGS, Journal of organic chemistry, 61(8), 1996, pp. 2726-2730
Citations number
49
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
61
Issue
8
Year of publication
1996
Pages
2726 - 2730
Database
ISI
SICI code
0022-3263(1996)61:8<2726:DFOSAT>2.0.ZU;2-Z
Abstract
Secondary and tertiary alkylzinc bromides can be generated from the di rect oxidative addition of Rieke zinc to secondary and tertiary alkyl bromides in high yield. These organozinc reagents have been found to u ndergo copper-catalyzed conjugate addition, cross-coupling with acid c hlorides, and carbocupration to activated alkynes.