EVALUATION OF FLOW-INJECTION SAMPLE TO STANDARD ADDITION METHOD FOR THE INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRIC DETERMINATION OF ALUMINUM IN BIOLOGICAL TISSUES

An on-line flow injection sample to standard addition method was devel oped for the determination of aluminium in biological tissues by induc tively coupled plasma mass spectrometry, The sample concentration is c alculated from two transient signals obtained from the injection of th e blank and the sample, using a standard solution as carrier. A flow i njection manifold for the on-line injection of both solutions was used and a three-step flow injection programme allowing the two transient signals to be obtained in the same measurement process was applied, A microwave nitric acid digestion procedure in closed vessels was used f or sample dissolution, and scandium was added as an internal standard to control plasma fluctuations and to correct for ion signal instabili ty, Tissue samples from healthy rat brain, kidney, liver, lung and spl een were analysed to find their aluminium concentrations, Complete rec overies from rat liver tissue spiked with aluminium concentrations in the 0.5-10.0 mu g g(-1) level were achieved, The detection limit (3 si gma) referred to the solid sample was of 10 ng g(-1) and the precision (RSD) was better than 1%, The accuracy of the proposed method was tes ted by determining the aluminium contents in two NIST Standard Referen ce Materials: SRM 1577b Bovine Liver and SRM 8414 Bovine Muscle Powder ).