A SIMPLE AND GENERAL-SYNTHESIS OF 4-OXO-4,5,6,7-TETRAHYDROINDOLES VIAA NOVEL INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION APPROACH

Authors
HUTCHISON DR NAYYAR NK MARTINELLI MJ
Citation
Dr. Hutchison et al., A SIMPLE AND GENERAL-SYNTHESIS OF 4-OXO-4,5,6,7-TETRAHYDROINDOLES VIAA NOVEL INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION APPROACH, Tetrahedron letters, 37(17), 1996, pp. 2887-2890
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
17
Year of publication
1996
Pages
2887 - 2890
Database
ISI
SICI code
0040-4039(1996)37:17<2887:ASAGO4>2.0.ZU;2-#
Abstract
A general synthesis of 4-keto-4,5,6,7-tetrahydroindoles 6-12 has been achieved in two steps using a new intramolecular 1,3-dipolar cycloaddi tion approach in moderate yields (45-60%). The potential of this metho dology is demonstrated by the synthesis of a mitomycin skeleton (15) a nd a topoisomerase-1 inhibitor skeleton (17). (C) 1996 Elsevier Scienc e Ltd