SOLID-PHASE SYNTHESIS OF PYRROLES DERIVED FROM A 4-COMPONENT CONDENSATION

Authors
MJALLI AMM SARSHAR S BAIGA TJ
Citation
Amm. Mjalli et al., SOLID-PHASE SYNTHESIS OF PYRROLES DERIVED FROM A 4-COMPONENT CONDENSATION, Tetrahedron letters, 37(17), 1996, pp. 2943-2946
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
17
Year of publication
1996
Pages
2943 - 2946
Database
ISI
SICI code
0040-4039(1996)37:17<2943:SSOPDF>2.0.ZU;2-7
Abstract
The first synthesis of tetra- and penta-substituted pyrroles via a 1,3 -dipolar cycloaddition of alkynes to polymer bound munchnones is repor ted. These munchnones are generated in a single step from a four compo nent condensation product of an aldehyde, an amine, a carboxylic acid and an isocyanide. The process produces pyrroles in good overall yield and high purity. (C) 1996 Elsevier Science Ltd