L. Moorhouse et al., SPECIFIC UPTAKE OF INTRACRANIAL HORSERADISH-PEROXIDASE (HRP) BY MICROGLIAL CELLS IN THE GOLDFISH, Neuroscience letters, 208(1), 1996, pp. 13-16
Intracranial injections of horseradish peroxidase (HRP) in the goldfis
h labeled a population of cells with many similarities to microglia. T
he fact that neither macroglia nor neurons appeared to be labeled by t
hese injections supports this identification. The labeled cells respon
ded to Wallerian degeneration of the optic paths by accumulating in th
e optic terminal zones, a cellular behavior which strongly supports th
eir identification as microglia.