The current status of analytic higher-order perturbative computations
of total cross sections and decay widths in Quantum Chromodynamics is
reviewed. Important issues are the methodology of renormalization-grou
p evaluations, the ambiguities of the renormalization scheme and its s
cale, and the technical challenge of calculating many-loop diagrams. A
s examples, the authors consider the quantities sigma(tot)(e(+)e(-) --
> hadrons) and Gamma(tau(-) --> nu(tau) + hadrons) up to O(alpha(s)(3)
) as well as Gamma(H --> hadrons) up to O(alpha(s)(2)). The evaluation
of the four-loop QED beta function is also described. The problem of
theoretical uncertainty estimates in perturbative calculations is brie
fly discussed.