Cia. Jack et al., LUNG-CANCER IN ELDERLY PATIENTS - THE ROLE OF INDUCED SPUTUM PRODUCTION TO OBTAIN A CYTOLOGICAL DIAGNOSIS, Age and ageing, 22(3), 1993, pp. 227-229
A single induced sputum sample using hypertonic saline and a ward nebu
lizer was obtained from 24/26 (92%) patients prior to fibreoptic bronc
hoscopy for suspected bronchial carcinoma. In 11 of the 19 patients la
ter found to have bronchial carcinoma, positive cytology was found in
the induced sputum sample (58% sensitivity), with no false positives (
100% specificity). These results are higher than those reported for or
dinary sputum samples. They suggest a possible role for this technique
in diagnosing bronchial carcinoma in elderly patients in whom broncho
scopy may be considered hazardous, or where this facility is not readi
ly available.