ATTENUATED VACCINIA VIRUS-CIRCUMSPOROZOITE PROTEIN RECOMBINANTS CONFER PROTECTION AGAINST RODENT MALARIA

Authors
LANAR DE TINE JA DETAISNE C SEGUIN MC COX WI WINSLOW JP WARE LA KAUFFMAN EB GORDON D BALLOU WR PAOLETTI E SADOFF JC
Citation
De. Lanar et al., ATTENUATED VACCINIA VIRUS-CIRCUMSPOROZOITE PROTEIN RECOMBINANTS CONFER PROTECTION AGAINST RODENT MALARIA, Infection and immunity, 64(5), 1996, pp. 1666-1671
Citations number
59
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
5
Year of publication
1996
Pages
1666 - 1671
Database
ISI
SICI code
0019-9567(1996)64:5<1666:AVVPRC>2.0.ZU;2-O
Abstract
NYVAC-based vaccinia virus recombinants expressing the circumsporozoit e protein (CSP) were evaluated in the Plasmodium berghei rodent malari a model system. Immunization of mice with a NYVAC-based CSP recombinan t elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogate d by in vivo CD8(+) T-cell depletion. Protection was not enhanced by m odification of the subcellular localization of CSP. These results sugg est the potential of poxvirus-based vectors for the development of vac cine candidates for human malaria.