PEPTIDE EPITOPES FROM NONCYTOSOLIC LISTERIA-MONOCYTOGENES CAN BE PRESENTED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES

Authors
ZWICKEY HL POTTER TA
Citation
Hl. Zwickey et Ta. Potter, PEPTIDE EPITOPES FROM NONCYTOSOLIC LISTERIA-MONOCYTOGENES CAN BE PRESENTED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES, Infection and immunity, 64(5), 1996, pp. 1870-1872
Citations number
20
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
5
Year of publication
1996
Pages
1870 - 1872
Database
ISI
SICI code
0019-9567(1996)64:5<1870:PEFNLC>2.0.ZU;2-F
Abstract
Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negat ive), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p60, a protein secreted by L. mo nocytogenes, to a class I-restricted CD8(+) cytotoxic T lymphocyte clo ne.