The oxygen isotope effect in high-T(C) superconductors has been invest
igated on the basis of a two-band model where superconducting phase tr
ansition is induced by interband (mainly Coulombic) interaction. The i
sotope shift of T(C) appears due to the dependence of averaged interba
nd electron-phonon coupling constant on oxygen mass. This coupling has
a repulsive nature and gives a relatively small contribution to the t
otal interaction inducing superconductivity. The calculated isotope ef
fect exponent depending on the carrier concentration has been compared
with the experimental one as a function of x for La2-xSrxCuO4.