ATRAZINE IN PLASMA AND TISSUE FOLLOWING ATRAZINE-AMINOTRIAZOLE-ETHYLENE GLYCOL-FORMALDEHYDE POISONING

A high performance liquid chromatography method has been used to study the plasma kinetics of atrazine in a human fatality after ingestion o f a herbicide mix containing atrazine, aminotriazole, ethylene glycol and formaldehyde. A hemodialysis was performed in an effort to elimina te these toxic substances. The mean atrazine clearance over 4 h was 25 0 mL/min and the dialysance of atrazine was calculated as 76%. On auto psy, the kidney showed the highest concentration of atrazine (97.62 mu g/g-1 wet tissue) with lesser concentrations in the lung, small intest ine and liver, and the lowest concentration in the heart.