LACK OF A KINETIC INTERACTION BETWEEN FLUCONAZOLE AND MEXILETINE

Objective. To investigate the effect of fluconazole on the kinetics of mexiletine. Methods. Six healthy male volunteers participated in a cr ossover study. On the Ist day, the subjects received 200 mg mexiletine alone. On days 2-7 they received 200 mg fluconazole orally, and on da y 8 they received 200 mg mexiletine and 200 mg fluconazole concomitant ly. In a third phase two subjects received 400 mg fluconazole daily. R esults. No differences in concentrations were observed between the thr ee phases. The area under the concentration curves (AUG) after adminis tration of mexiletine alone and in combination with fluconazole 200 mg /day were 6.63 and 7.31 mu g . h . ml(-1), respectively. Conclusion. T hese findings suggest that fluconazole does not inhibit mexiletine met abolism.