SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOLOGICAL-ACTIVITY OF PALLADIUM(II) AND PLATINUM(II) COMPLEXES WITH DITHIOCARBAMIC ACIDS ANDTHEIR DERIVATIVES AS LIGANDS

We report the preparation and characterization of new complexes of pal ladium (II) and platinum (H) with some heterocyclin containing dithioc arbamate ligands, such as piperidine-, morpholine-, and thiomorpholine -dithiocarbamate, their methyl esters and the corresponding thiouramdi sulphides. These compounds have been studied through spectroscopic tec hniques, IR spectra, and electronic spectra, thermogravimetric and con ductivity measurements. Thermal decomposition of the complexes takes p lace through a multi-step process involving pyrolysis of the organic m oiety that leads to palladium oxide and platinum sponge respectively. All the complexes have been tested for cytostatic activity on KB cells and the most effective compounds also against L1210 and P388 cells.