ANALYSIS OF RNA SEQUENCE STRUCTURE MAPS BY EXHAUSTIVE ENUMERATION .1.NEUTRAL NETWORKS

Global relations between RNA sequences and secondary structures are un derstood as mappings from sequence space into shape space. These mappi ngs are investigated by exhaustive folding of all GC and AU sequences with chain lengths up to 30. The computed structural data are evaluate d through exhaustive enumeration and used as an exact reference for te sting analytical results derived from mathematical models and sampling based on statistical methods. Several new concepts of RNA sequence to secondary structure mappings are investigated, among them that of neu tral networks (being sets of sequences folding into the same structure ). Exhaustive enumeration allows to test several previously suggested relations: the number of(minimum free energy) secondary structures as a function of the chain length as well as the frequency distribution o f structures at constant chain length (commonly resulting in generaliz ed forms of Zipf's law).