SYNTHESIS OF 5-METHYLISOCYTIDINE DERIVATIVES

Authors
ABDELRAHMAN AAH PEDERSEN EB NIELSEN C
Citation
Aah. Abdelrahman et al., SYNTHESIS OF 5-METHYLISOCYTIDINE DERIVATIVES, Monatshefte fuer Chemie, 127(4), 1996, pp. 455-459
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
127
Issue
4
Year of publication
1996
Pages
455 - 459
Database
ISI
SICI code
0026-9247(1996)127:4<455:SO5D>2.0.ZU;2-6
Abstract
N-2-Substituted 5-methylisocytidine derivatives were synthesized from S-2-methyl-2-thiothymine either by direct substitution of the methylth io group by an amino group and subsequent condensation with 1,2,3,5-te tra-O-acetyl-beta-D-ribofuranose to give the acetylated nucleoside or by the opposite sequence first preparing an acetylated S,S-2-dimethyl- 2-thiouridine followed by treatment with the appropriate amine.