INFLUENCE OF MAXIMAL ERGOMETRIC EXERCISE AN ENDOTHELIN CONCENTRATIONSIN RELATION TO MOLECULAR MARKERS OF THE HEMOSTATIC SYSTEM

The effects of moderate 30 min cycle ergometer exercise !aerobic metab olism 0.85-3.71 mmol . l(-1) lactate) followed by short-term exercise at maximal capacity (anaerobic metabolism: 5.09 to 17.75 mmol . l(-1) lactate) on endothelin (ET) and hemostatic variables (tissue plasminog en activator [t-PA] antigen, prothrombin fragments [F-1,F-2], thrombin -antithrombin III complex [TAT], prothrombin time and partial thrombop lastin time) were investigated in 15 male healthy subjects of varying fitness levels. Endothelin was measured twice, before and immediately after maximal cycle exercise. The results show an increase in endothel in concentration [10.0 pg . ml(-1) (baseline) + 6.1 pg . ml(-1) (incre ase post exercise)]. ET did not increase under control conditions. Mod erate 30 min exercise caused an increase in t-PA antigen concentration (3.66 + 3.15 ng . ml(-1)) and short-term maximal exercise produced a markedly higher elevation in this variable (+ 10.6 ng . ml(-1)). F-1,F -2 increased (810 + 40 pmol . l(-1)) under moderate and by 150 pmol . l(-1) under anaerobic exercise. TAT increased only at maximal exercise levels (1.01 + 0.32 ng . l(-1)). No changes were found in any of thes e variables under control conditions. No correlation of endothelin and the hemostatic variables was found. It is concluded that endothelin a nd hemostatic markers increase independently during moderate and maxim al exercise.