SIMULTANEOUS OCCURRENCE OF LARGE B-CELL NON-HODGKIN-LYMPHOMA AND MYELODYSPLASTIC SYNDROME RAPIDLY EVOLVING INTO ACUTE MYELOBLASTIC-LEUKEMIA

We describe a case of simultaneous occurrence of large B-cell non-Hodg kin lymphoma and myelodysplastic syndrome in the absence of previous c hemotherapy or radiotherapy. After initiation of steroid treatment, th e myeloid clone showed a rapid increase in both the bone marrow and pe ripheral blood with transformation into acute myeloid leukemia. The di agnosis were confirmed by immunophenotypic studies performed in the hi stologic sections of the lymph node, as well as in bone marrow and per ipheral blast cells. This case may be indicative of potential down-reg ulation of a malignant myeloid clone induced by the malignant lymphoid clone.