MYELODYSPLASTIC SYNDROME-ASSOCIATED WITH HYPOTRIPLOIDY

We describe a case of de novo myelodysplastic syndrome (MDS) with hypo triploidy, a condition in which polyploid chromosome abnormalities are rarely observed. A 64-year-old male was diagnosed with refractory ane mia with ring sideroblasts (RARS). Cytogenetic analysis of bone marrow cells revealed 65,X,-Y,+2,+6,-7,+8,-9,-10,+11,-12, add(12)(p11.2),+14 ,-16,-18,-19,-20, -21,-21,+3mar[11/22]/46,XY[11/22]. One month later, rapid transformation to refractory anemia with excess of blasts in tra nsformation was observed in spite of a hematological improvement obtai ned by therapy with corticosteroids, anabolic steroids and pyridoxine. Two months after the diagnosis of RARS, he died of multiple organ fai lure. In our case, the hypotriploid chromosome abnormality may have re presented a poor prognosis.