A NEW METHOD FOR THE SYNTHESIS OF 2-GLYCOSYLAMINO PYRIDINES

Authors
COBO J MELGUIZO M SANCHEZ A NOGUERAS M DECLERCQ E
Citation
J. Cobo et al., A NEW METHOD FOR THE SYNTHESIS OF 2-GLYCOSYLAMINO PYRIDINES, Tetrahedron, 52(16), 1996, pp. 5845-5856
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
16
Year of publication
1996
Pages
5845 - 5856
Database
ISI
SICI code
0040-4020(1996)52:16<5845:ANMFTS>2.0.ZU;2-L
Abstract
Several 2-glycosylaminopyridines 7, were synthesized through a tandem Diels-Alder/Retro Diels-Alder (DA/RDA) reaction starting from 6-glycos ylaminopyrimidines, 6, with dimethyl acetylenedicarboxylate (DMAD) as dienophile. This approach represents a new method for the synthesis of 2-aminopyridine nucleoside analogues. The compounds were tested for t heir antiviral activity but did not prove active. Copyright (C) 1996 E lsevier Science Ltd