WITTIG OLEFINATION OF METHYL 1S,2R)-1-BENZAMIDO-2-FORMYLCYCLOPROPANECARBOXYLATE - A POWERFUL TOOL FOR THE SYNTHESIS OF NEW CONFORMATIONALLYCONSTRAINED CYCLOPROPYL AMINO-ACIDS

The behaviour of methyl 1S,2R)-1-benzamido-2-formylcyclopropanecarboxy late with stabilised and semi-stabilised ylids has been tested in orde r to evaluate its synthetic utility in the synthesis of cyclopropyl am ino acids by Wittig olefination. Wittig adducts were further elaborate d to obtain the corresponding cyclopropyl amino acids in high yields a nd enantiomerically pure form. Copyright (C) 1996 Elsevier Science Ltd