DIFFERENCES IN THE NYCTOHEMERAL SECRETION OF TSH AND PRL IN HEALTHY EUTHYROID MEN

Citation
Jse. Derickstan et al., DIFFERENCES IN THE NYCTOHEMERAL SECRETION OF TSH AND PRL IN HEALTHY EUTHYROID MEN, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 104(2), 1996, pp. 145-150
Citations number
41
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
09477349
Volume
104
Issue
2
Year of publication
1996
Pages
145 - 150
Database
ISI
SICI code
0947-7349(1996)104:2<145:DITNSO>2.0.ZU;2-R
Abstract
The circadian rhythm of TSH, PRL and cortisol was studied in 21 health y euthyroid men in a normal sleep/wake cycle. Higher nyctohemeral (22. 00 h till 6.00 h) levels of TSH as compared to diurnal (8.00 h till 22 .00 h) levels were observed in 14 out of 21 men (Group A). In the rema ining 7 volunteers the nyctohemeral and diurnal TSH-levels (Group B) w ere the same. In Group A, the nyctohemeral PRL-surge was also higher t han in Group B (p < 0.01). The nyctohemeral area under the curve (AUC) of both TSH and PRL were significantly higher in Group A than in Grou p B (p < 0.05 and p < 0.001 respectively). The mean diurnal concentrat ions of TSH and PRL were, however, similar in both groups. Therefore, an impairment of the nyctohemeral TSH-surge can occur in healthy men u sually combined with a reduced nyctohemeral PRL-surge. An impairment o f nyctohemeral TSH-surge is thus not confined to patients with thyroid diseases.