DOUBLE-BLIND RANDOMIZED TRIAL OF 2 ANTIHY PERTENSIVE COMBINATIONS - ENALAPRIL-HYDROCHLOROTHIAZIDE VS ENALAPRIL-NIFEDIPINE IN 240 PATIENTS RESISTANT TO MONOTHERAPY
Y. Frances et al., DOUBLE-BLIND RANDOMIZED TRIAL OF 2 ANTIHY PERTENSIVE COMBINATIONS - ENALAPRIL-HYDROCHLOROTHIAZIDE VS ENALAPRIL-NIFEDIPINE IN 240 PATIENTS RESISTANT TO MONOTHERAPY, Therapie, 51(1), 1996, pp. 35-39
The combination of two antihypertensive drugs is recommended when mild
to moderate hypertension is not controlled by sequential monotherapy.
The aim of our study was to compare the efficacy and the safety of th
e combination enalapril 20 mg - hydrochlorothiazide 12.5 mg to that of
enalapril 20 mg - nifedipine SL 20 mg x 2. Two hundred and forty four
hypertensive patients not controlled (DPB > 95 mmHg) by a single dose
of enalapril 20 mg/24 h, received for 4 weeks, one of these two combi
ned therapies in a randomized double-blind trial. The efficacy was of
same amplitude in the two groups (DBP: -10.8 mmHg enalapril-hydrochlor
othiazide vs - 10.3 mmHg enalapril-nifedipine). The side effects were
less frequent in the enalapril-hydrochlorothiazide group (14 per cent
vs 24 per cent, p=0.04).