SYNTHESIS OF 2',3'-ANHYDRONUCLEOSIDES OF PYRAZOLO[3,4-D]PYRIMIDINE ASANTIVIRAL AGENTS

Authors
TRIPATHI RP MISHRA A PRATAP R BHAKUNI DS
Citation
Rp. Tripathi et al., SYNTHESIS OF 2',3'-ANHYDRONUCLEOSIDES OF PYRAZOLO[3,4-D]PYRIMIDINE ASANTIVIRAL AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(5), 1996, pp. 441-445
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
35
Issue
5
Year of publication
1996
Pages
441 - 445
Database
ISI
SICI code
0376-4699(1996)35:5<441:SO2OPA>2.0.ZU;2-R
Abstract
thylthio-N-1-(2',3'-anhydro-beta-D-lyxofuranosyl), and o-beta-D-ribofu ranosyl)-pyrazolo[3,4-d]pyrimidines (10 and 17) have been synthesized by 2',3'transelimination of the corresponding N-1(9)- and 2)-beta-D-xy lofuranosylpyrazolo[3,4-d]pyrimidines. The compounds and their interme diates have been screened for their antiviral activities against RDV a nd EMCV exhibiting 10-100% activity.