Je. Ogden et Pk. Moore, INHIBITION OF NITRIC-OXIDE SYNTHASE - POTENTIAL FOR A NOVEL CLASS OF THERAPEUTIC AGENT, Trends in biotechnology, 13(2), 1995, pp. 70-78
The free-radical gas nitric oxide (NO) plays an important role in a wi
de and diverse range of physiological processes. As progress is made i
n understanding the biological function of NO, there is growing intere
st in the possibility that inhibitors of NO synthase (NOS) may be of c
linical use in the therapy of certain disease states. The search for n
ovel and clinically relevant inhibitors of this enzyme represents a tr
uly multidisciplinary approach to drug screening and will no doubt ben
efit from the application of recombinant DNA (rDNA) technology.