Human granulocytic ehrlichiosis is a tick-borne disease of humans. Inv
olvement of the peripheral nervous system is well known with Lyme dise
ase and some rickettsioses but has yet to be described with this disea
se. We describe a man with bilateral brachial plexopathies associated
with an acute febrile illness and clinical, laboratory, and serologic
evidence diagnostic of human granulocytic ehrlichiosis. The clinical p
resentation suggests that the peripheral neuropathy was postinfectious
. Human granulocytic ehrlichiosis should be considered in the differen
tial diagnosis in patients with peripheral nervous system involvement,
including brachial plexopathy, of individuals who live or recreate in
areas known to harbor ticks.