We investigated five patients with a locked-in-syndrome (LIS) and repo
rted the clinical, electrophysiologic, neuroradiologic, and neuropatho
logic findings. EEG reactivity was present in two and absent in three
cases. Somatosensory evoked potentials (SEP) varied from unilaterally
normal to bilaterally absent. We conclude that there is no specific pa
ttern of SEP abnormality characteristic of LIS and that EEG reactivity
cannot be taken as a sole measure of consciousness.