NORMAL-DISTRIBUTION OF APOLIPOPROTEIN-E ALLELES IN PROGRESSIVE SUPRANUCLEAR PALSY

Authors
ANOUTI A SCHMIDT K LYONS KE HUBBLE JP SCHELLENBERG G GOLBE LI LANG AE GALVEZJIMENEZ N HERSHEY L KOLLER WC
Citation
A. Anouti et al., NORMAL-DISTRIBUTION OF APOLIPOPROTEIN-E ALLELES IN PROGRESSIVE SUPRANUCLEAR PALSY, Neurology, 46(4), 1996, pp. 1156-1157
Citations number
17
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
46
Issue
4
Year of publication
1996
Pages
1156 - 1157
Database
ISI
SICI code
0028-3878(1996)46:4<1156:NOAAIP>2.0.ZU;2-T
Abstract
Apolipoprotein E (Apo E) genotype is a genetic risk factor influencing the development of Alzheimer's disease (AD). Progressive supranuclear palsy (PSP), like AD, is a dementing illness with neurofibrillary tan gles. We determined the frequencies of Apo E alleles in 52 PSP patient s and 52 age- and gender-matched controls. The distribution of Apo E a llele frequencies and genotypes showed no difference between PSP and c ontrols. Apo E allele status does not influence the development of PSP .