MAGNETIC-RESONANCE-IMAGING AND NEUROLOGICAL EVALUATION AFTER TREATMENT WITH HIGH-DOSE METHOTREXATE FOR ACUTE LYMPHOCYTIC-LEUKEMIA IN YOUNG-CHILDREN

Citation
H. Seidel et al., MAGNETIC-RESONANCE-IMAGING AND NEUROLOGICAL EVALUATION AFTER TREATMENT WITH HIGH-DOSE METHOTREXATE FOR ACUTE LYMPHOCYTIC-LEUKEMIA IN YOUNG-CHILDREN, Acta paediatrica, 85(4), 1996, pp. 450-453
Citations number
22
Categorie Soggetti
Pediatrics
Journal title
ISSN journal
08035253
Volume
85
Issue
4
Year of publication
1996
Pages
450 - 453
Database
ISI
SICI code
0803-5253(1996)85:4<450:MANEAT>2.0.ZU;2-9
Abstract
This study evaluates the occurrence of permanent cerebral white matter changes and neurological abnormalities in children treated at a young age for acute lymphocytic leukaemia. Our pilot treatment protocol did not include central nervous system irradiation, but intrathecal metho trexate and high-dose methotrexate infusions followed by very intensiv e folinic acid rescue. We examined 12 children in complete remission a nd off therapy 18 months to 9.5 years after their last methotrexate in fusion. They were below 5 years of age at diagnosis and therefore expe cted to be at special risk of neurotoxic sequelae. Cerebral magnetic r esonance imaging in the 11 cases thus evaluated did not reveal white m atter abnormalities or other signal changes as signs of permanent trea tment-related sequelae. We did not observe any pathological clinical n eurological findings likely due to methotrexate.