TARGET THERAPY OF OVARIAN-CARCINOMA BY MONOCLONAL-ANTIBODIES BEARING CHEMICAL DRUGS ENTRAPPED IN LIPOSOMES

Monoclonal antibody COC166-9 against ovarian carcinoma was conjugated with adriamycin or cisplatinum entraped in liposomes as immunochemical liposomes MLA and MLP respectively. MLA was shown to have the highest effect than adriamycin or other groups on SKOV3 (ovarian cancer cell line) growth inhibition. MLA was also used in target therapy on nude m ice bearing human ovarian carcinoma by xenograft of SKOV3 cells. The o bservations of tumor volumes revealed that this target therapy other t han the controls presents a significantly better result which gives a hopeful clue to ovarian carcinoma treatment.