COMPUTER-ASSISTED SEARCH FOR SITES OF NUCLEAR MATRIX ATTACHMENT

This communication describes a useful approach for assessing the signi ficance of the occurrence of multiple motifs within defined segments o f the genome. Regions of potential biological importance are identifie d using various sequence motifs, and then the results are displayed as their cumulative statistically weighted distribution. We illustrate t he utility of this strategy to the search for known nuclear matrix-ass ociated regions by its application to the human beta-globin and other loci. (C) 1996 Academic Press, Inc.