A HUMAN RNA-POLYMERASE-II COMPLEX-ASSOCIATED WITH SRB AND DNA-REPAIR PROTEINS

Authors
MALDONADO E SHIEKHATTAR R SHELDON M CHO H DRAPKIN R RICKERT P LEES E ANDERSON CW LINN S REINBERG D
Citation
E. Maldonado et al., A HUMAN RNA-POLYMERASE-II COMPLEX-ASSOCIATED WITH SRB AND DNA-REPAIR PROTEINS, Nature, 381(6577), 1996, pp. 86-89
Citations number
31
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
381
Issue
6577
Year of publication
1996
Pages
86 - 89
Database
ISI
SICI code
0028-0836(1996)381:6577<86:AHRCWS>2.0.ZU;2-L
Abstract
WE report here the isolation of a human RNA polymerase II complex cont aining a subset of the basal transcription factors and the human homol ogues of the yeast SRB (for suppressors of RNA polymerase B) proteins( 1-3). The complex contains transcriptional coactivators and increases the activation of transcription, In addition, some components of the R NA polymerase II complex participate in DNA repair.