PLEIOTROPIC FUNCTIONS OF ETS-1 (REVIEW)

Authors
BHAT NK FISCHINGER PJ SETH A WATSON DK PAPAS T
Citation
Nk. Bhat et al., PLEIOTROPIC FUNCTIONS OF ETS-1 (REVIEW), International journal of oncology, 8(5), 1996, pp. 841-846
Citations number
44
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
8
Issue
5
Year of publication
1996
Pages
841 - 846
Database
ISI
SICI code
1019-6439(1996)8:5<841:PFOE(>2.0.ZU;2-P
Abstract
ETS-1 is a cellular homologue of the viral ets oncogene of the E26 vir us and functions as a sequence specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid ce ll development, transformation, angiogenesis and apoptosis. ETS-1 may control the expression of critical genes involved in these processes b y binding to ets binding sites present in their transcriptional regula tory regions. Recent progress in understanding the multiple functions of ETS-1 is summarized in this review.