A MORPHOMETRIC STUDY ON THE NUCLEAR MATRIX OF TUMOR-CELLS IN-VITRO

Citation
L. Yang et al., A MORPHOMETRIC STUDY ON THE NUCLEAR MATRIX OF TUMOR-CELLS IN-VITRO, International journal of oncology, 8(5), 1996, pp. 977-981
Citations number
22
Categorie Soggetti
Oncology
ISSN journal
10196439
Volume
8
Issue
5
Year of publication
1996
Pages
977 - 981
Database
ISI
SICI code
1019-6439(1996)8:5<977:AMSOTN>2.0.ZU;2-5
Abstract
Recently, we have demonstrated that two cervical carcinoma cell lines with different cell differentiation stages possessed different nuclear matrix stability. The nuclear matrix of poorly differentiated cells w as more stable than that of the more differentiated one. In the presen t study, we further quantified the nuclear matrix density after treatm ent with different DNase I concentrations. Moreover, six more ovarian cell lines were also used to investigate the relationship between nucl ear matrix stability and cell differentiation stages. Since the nuclea r matrix is an important site for gene replication and transcription, the nuclear matrix stability can be used as an indicator to reflect th ese activities within the nucleus.