Recently, we have demonstrated that two cervical carcinoma cell lines
with different cell differentiation stages possessed different nuclear
matrix stability. The nuclear matrix of poorly differentiated cells w
as more stable than that of the more differentiated one. In the presen
t study, we further quantified the nuclear matrix density after treatm
ent with different DNase I concentrations. Moreover, six more ovarian
cell lines were also used to investigate the relationship between nucl
ear matrix stability and cell differentiation stages. Since the nuclea
r matrix is an important site for gene replication and transcription,
the nuclear matrix stability can be used as an indicator to reflect th
ese activities within the nucleus.