ATYPICAL NEUROLEPTICS - THEIR CONTRIBUTION TO THE REHABILITATION OF SCHIZOPHRENIC-PATIENTS

Therapeutic effects of neuroleptics (NLP) in schizophrenia are well es tablished in numerous international studies. Varying modalities of evo lution under NLP treatment are described and require a clinical analys is. Neuroleptics are a necessary but insufficient condition for the th erapy of schizophrenia Via NLP treatment, other therapeutic approaches , such as psychotherapy, or sociotherapy become more effective. Consec utively, we present the effects of two compounds with dopaminergic sel ective activity (amisulpride, remoxipride) and of two other compounds with non-selective activity (risperidone, clozapine) regarding rehabil itation in schizophrenic patients. Data were collected from internatio nal studies with a medico-economic perspective and from French experie nce of clozapine in refractory schizophrenic patients. All these data stress the importance of several areas of study: clinical features, ev eryday life consequences and therapeutical effects observed with the a typical neuroleptics.